Mixed Hyperlipidemia – Symptoms, Causes, And Treatment

Mixed hyperlipidemia or high cholesterol can refer to elevated levels of fats in the blood. Most of the people do not usually experience any hyperlipidemia symptoms.

But having hyperlipidemia can increase the risk of developing heart disease and also increases the risk of stroke and death.  In the United States, about 1 in 3 people are suffering from mixed hyperlipidemia.

If you want to know, the cause, symptoms, and treatment of mixed hyperlipidemia, then keep reading this blog.

Before knowing about the mixed hyperlipidemia, you need to know what hyperlipidemia is. So let’s check out. 


What Is Hyperlipidemia?

cholesterol level

Hyperlipidemia meaning there is too much cholesterol in the blood. Cholesterol is a waxy fat molecule that the liver can produce.

It is important for healthy cell membranes, vitamin storage, hormone production, and brain functioning.

In the body there are two types of lipoprotein or protein present that can transport the cholesterol to the cells these are: 

  • Low-density lipoproteins or a bad cholesterol 
  • High-density lipoproteins or a good cholesterol

LDL can cause damaging effects on health. However,  HDL can counteract the effects of LDL.

While HDL is good for the health because it carries the excess cholesterol which is back to the liver for the excretion. Then  the liver can eliminate the cholesterols through the bile.

LDL that remains in the bloodstream can damage the health because it allows the excess cholesterol to build up in the blood. The triglycerides are also another type of fat in the blood.

It is not a type of cholesterol, but it strongly associated with heart [1]disease. Because of this doctors also measure the triglyceride level in the body, people who have hyperlipidemia.

These fats enter the walls of the arteries and incense the risk for developing hardening of the arteries. That can cause the hyperlipidemia complications such as heart attack disease or stroke.

If any person has one or the combination of the following then they can develop hyperlipidemia. 

  • High level of LDL or bad cholesterol
  • High level of HDL or good cholesterol 
  • Elevated triglycerides

Here are the table that can highlights the ideal cholesterol levels:

  • Overall cholesterol: under 200 milligrams per deciliter mg/dl
  • HDL cholesterol: More than 40 mg/dl in men and more than 50 mg/dl in the women
  • LDL cholesterol: Less than 100 mg/dl in healthy people and less than 70 mg/dl in those people who have heart disease, diabetes, or poorly controlled risk factors.
  • Triglycerides: Less than 150 mg/dl 

Hyperlipidemia or a high cholesterol level can also cause cardiovascular diseases.

That’s why it is important to control hyperlipidemia with lifestyle changes and also with medication. 

What Does Mixed Hyperlipidemia Mean? 

heart problem

Mixed hyperlipidemia is a genetic disorder that can pass down through family members. If you also have this disease, then it means you have higher levels of cholesterol, triglycerides, and other lipids in your blood.

This disorder also contributes to heart diseases and early heart attacks. Alcohol, diabetes, obesity, and hypothyroidism can make this condition worse.

Mixed hyperlipidemia is also known as the familial that can combine the hyperlipidemia. It also affects an estimated 1 to 2 percent of the population in the western world. In fact, it is also the most common inherited lipid disorder.

The high lipid levels typically begin in the teenage years. According to some evidence hyperlipidemia, it begins in childhood for some people.  

Types Of Mixed Hyperlipidemia 

The mixed hyperlipidemia is basically classified as either familial which is known as the primary, this will be caused by the specific genetic abnormalities or the acquired it also called secondary.

When it results from the other underlying disorders that can lead to alteration in the plasma lipid and lipoprotein metabolism.

The hyperlipidemias are also classified according to which types of lipids are elevated that are combined hyperlipidemia, hypertriglyceridemia, and hypercholesterolemia.

The elevated lipoproteins are also classified as a form of hyperlipidemia. Here are the types of hyperlipidemia that doctors categorize according to their types of fat they involve and these types are the impact on the body. 

1. Familial Or Primary

Familial hyperlipidemia classifies according to the Fredrickson classifications. That is based on the pattern of lipoproteins on the electrophoresis or the ultracentrifugation.

This was later adopted by the WHO. It also not directly account for HDL and it does not distinguish among the different genes that may be responsible for some of these conditions. 

Mixed Hyperlipidemia Type 1

Type 1 of the mixed hyperlipidemia familial is the deficiency of lipoprotein lipase. It typically occurs in childhood and it is also severe.

It is an inherited condition that can disrupt the normal breakdown of the fats and lead the patient to abdominal pain, repeat infections of the pancreas and also the enlargement of the spleen and liver. 

Type 2 (a and b)

Type 2a or familial hypercholesterolemia and type 2b or the familial combined hyperlipidemia both are caused by the high levels of LDL.

This type of mixed hyperlipidemia can lead to deposits of fat in around the eyes. This will also increase the risk of heart problems. 

Type 3

Type 3 or the familial dysbetalipoproteinemia can affect the lipoproteins. It also occurs when the level of LDL in the blood is too low, but the HDL cholesterol levels remain normal.

A typical feature of type 3 mixed hyperlipidemia is the occurrence of xanthomas or the flat, yellow -gray plaques on the eyelids and also around the eyes. 

This type of mixed hyperlipidemia also increases the risk of early-onset cardiovascular and peripheral artery disease in the body. 

Type 4

Type 4 or hypertriglyceridemia can be caused by the increasing levels of the triglycerides in the blood rather than the cholesterol level.

This type of mixed hyperlipidemia can lead to obesity, high insulin levels, and also high blood glucose.

The person who has a type 4 hyperlipidemia may not notice any symptoms until thorough adulthood. 

Type 5 

Type 5 or the hyperlipoproteinemia is also known as the mixed hyperlipoproteinemia familial or mixed hyperlipidemia.

It is very similar to the type 1 hyperlipidemia but with a high VLDL in addition to the chylomicrons. It also associated with glucose intolerance and hyperuricemia.

2. Acquired Or Secondary

Acquired mixed hyperlipidemia also called secondary dyslipoproteinemias. It often mimics primary forms of hyperlipidemia and it contains similar consequences.

This may result in an increased risk of premature atherosclerosis when it is associated with hypertriglyceridemia.

It may also lead to pancreatitis and other complications of the chylomicronemia syndrome. The most common cause of acquired hyperlipidemia are:

  • Uses of drugs such as beta-blockers, estrogens, thiazide diuretics
  • Diabetes mellitus

Some other condition that leads to the acquired hyperlipidemia include:

  • Kidney syndrome 
  • Hypothyroidism
  • Alcohol consumption
  • Nephrotic syndrome
  • Some rare metabolic disorders and endocrine disorders

What Are The Causes Of Mixed Hyperlipidemia? 

getting tired man on treadmill

As I told you before the mixed hyperlipidemia meaning a high cholesterol level. But there is still scientific research ongoing to know the specific genes that can cause this disorder.

The research is still complex because the characteristics of mixed hyperlipidemia can overlap with those of metabolic syndrome. This syndrome is not genetically determined and it is more widespread.

But the new genetic research technique and the statistics are helping the scientist to understand what is the cause of the mixed hyperlipidemia.

According to a Kaiser Permanente report[3], if one parent has mixed hyperlipidemia, then there is a 50% chance of inheriting the genetic risk of the disorder in their baby.

If both parents are having mixed hyperlipidemia, then they may inherit a double dose[2] in the baby that can cause more serious medical problems in their early life.

Hyperlipidemia is also caused when you are consuming too much fat, cholesterol, and carbohydrates diets such as meat, cream, eggs, shellfish, and cheese. Some people are also born with mixed hyperlipidemia.

This defect can also prevent the body from ridding itself of the type of cholesterol that can build up in the arteries and cause heart-related disease.

This type of cholesterol is called low-density lipoprotein, but it is also commonly known as bad cholesterol. The bad cholesterol can cause arteries to get harder and narrow.

This will also increase the risk of heart attack or heart disease. Here is some preventable cause of mixed hyperlipidemia: 

  • Being overweight
  • Smoking 
  • A diet that is high in fat, cholesterol, and saturated fat. 
  • Steroid use
  • Excessive alcohol consumption 
  • Physical inactivity

Mixed Hyperlipidemia Signs and Symptoms

heart pain

Usually, the people who have hyperlipidemia do not experience any symptoms. However, the familiar people, or inherited hyperlipidemia, may develop the yellow and fatty growth around their eye or the joints.

A doctor detects the hyperlipidemia during a routine blood test or following a cardiovascular enters which includes, stroke or heart attack. When excessive fat is buildup over time than it can cause atherosclerosis.

This occurs when the plaques are developed on the walls of the arteries, the blood vessels, and also narrow the openings. This can lead to unstable blood flow through the vessels and it can increase the risk of stroke and heart disease.

When the mixed hyperlipidemia symptoms appear then they may include: 

  • Cramping on one or both calves while walking.
  • Chest pain or the other signs of coronary artery disease that may be present at a young age. 
  • Sores on the toes
  • Sudden stroke-like symptoms  such as weakness of an arm or leg, drooping on one side of the face, loss of balance and trouble speaking
  • Blockage of blood vessels in the brain and heart 
  • High blood pressure 
  • Stroke
  • Heart attack

The people with this condition may also experience a high cholesterol or high triglyceride levels as teenagers. The mixed hyperlipidemia symptoms can also diagnose when the people are in their 20s and 30s.

The cholesterol levels remain high all during their life. Those people who have familial mixed hyperlipidemia may have a risk of early coronary artery disease and heart attacks.

They may also have a higher rate of obesity and they are more likely to have glucose intolerance. 

What Are The Risk Factors of Mixed Hyperlipidemia?

drink alcohol

The risk of mixed hyperlipidemia is high if one or both parents have the gene defect that can cause it. Most people who have mixed hyperlipidemia are getting one affecting gene.

But in rare cases, the child can get the affecting gene from both parents. This can cause more severe health conditions. The mixed hyperlipidemia inherits and also causes high lipid levels.

The lipid  levels will even get higher if you have the following conditions:  

  • Diabetes 
  • Obesity 
  • Hypothyroidism 
  • Alcohol abuse 

The high level of mixed hyperlipidemia can put you at a risk which includes:

  • Coronary heart disease 
  • Stroke
  • Peripheral vascular disease
  • Early heart attack
  • Taking medications such as steroids or hormone
  • Metabolic syndrome 
  • Long term kidney disease 
  • Premature menopause 
  • Sedentary lifestyle 
  • Pregnancy menopause 
  • Pregnancy 

A parent can passses down a mutated gene that leads to a missing or the malfunctioning LDL receptor. This means that the body cannot clear LDL from the bloodstream that can cause dangerous levels of LDL in the blood.

Some ethnic groups such as Christian Lebanese, French Canadians, and a specific population from South Africa include Ashkenazi Jews, Afrikaners, and Asian Indians can have a higher risk of familial hyperlipidemia. 

Differential Diagnosis For Hyperlipidemia

Blood Pressure

Mixed hyperlipidemia is first noticed when the blood tests will indicate high lipid levels. The patient may not have any physical hyperlipidemia symptoms.

But knowing the family history, especially of heart disease or hyperlipidemia can help the doctor to make a diagnosis. The genetics research can progress.

The medical professionals may also develop a genetic test for the mixed hyperlipidemia and the treatments that can target the genes involved. Currently, doctors will need to perform blood tests to make a diagnosis.

All the tests can also help the doctor to determine the levels of lipids in the blood.

So, the doctor will look for lower than the average level of HDL cholesterol and higher levels of LDL cholesterol, triglycerides, and apolipoprotein B100.

The results of these tests may indicate mixed hyperlipidemia. The blood test can require fasting for 12 hours before the test. Which means the patient can’t eat or drink expecting water before the test.

Doctors will ask the patients about any drug supplements that they usually take. The doctor will tell them whether or not to take those before the test.

Some of the doctors may also use a carotid ultrasound as a diagnostic tool. It’s not invasive or expensive, plus it can also help you to predict the future stroke of a heart attack.

Most of the children also go through the screening. Here is the screening or differential diagnosis of hyperlipidemia. 


Adults 20 years and also older should have the cholesterol check every 4 to 6 years.

The serum levels of the low-density lipoproteins cholesterol, triglycerides, and the high-Density Lipoproteins are commonly tested in the primary care settings by using a lipid panel.

The quantitative level of lipoprotein and triglycerides can contribute towards cardiovascular disease risk stratifications via models such as the Framingham risk score.

Reynold risk scores, ACC, AHA atherosclerotic Cardiovascular Disease risk estimator.

These models may also take into account, the family history, gender, age, medical history, high sensitivity CRP levels, ankle-brachial index, coronary artery calcium score, and body mass index.

The cardiovascular stratification further determines what is medical intervention is necessary to decrease the risk of future cardiovascular disease.  

Total Cholesterol Levels

Combine the quantity of HDL and LDL. The total cholesterol level is higher than the  240 mg/dl is abnormal, but in the medical intervention, it can be determined by the breakdown of HDL and LDL levels. 

LDL Cholesterol 

LDL cholesterol is also known as bad cholesterol. This cholesterol is also associated with an increase in the risk of cardiovascular disease.

LDL cholesterol can transport the cholesterol particles throughout the body and it can also build up in the walls of the arteries and make them narrow and hard.

LCL cholesterol can be produced naturally by the body, but eating a high saturated fat diet, trans fat and cholesterol can increase the LDL levels.

The elevated LDL level is also associated with atherosclerosis, hypertension, hypertriglyceridemia, and diabetes.

In the fasting lipid panel, and LDL is greater than 160 mg/dl which is abnormal. 

HDL Cholesterol 

HDL cholesterol is also known as good cholesterol which is associated with the decreased risk of cardiovascular disease.

The HDL cholesterol carries the cholesterol from other parts of the body back to the liver, then it removes the cholesterol from the body.

It can get affected by the Accuride or the genetic factors which include: tobacco use, diabetes, genetic abnormalities, obesity, inactivity, high carbohydrates diet, hypertriglyceridemia.

It also gets affected by the side effects of medication such as oral estrogens, retinoic acid derivatives, beta-blockers, corticosteroids, thiazide diuretics, progestogens, and androgenic steroids.

HDL cholesterol low level can define as less than 40 mg/dl. 


The triglycerides level in the independent risk of cardiovascular diseases and metabolic syndrome. The food intake before the testing can cause elevated triglycerides levels up to 20%.

The normal level is defined as less than 150mg. While the borderline high can define as 150mg/dl to 199mg/dl and the high level is between 200 and 499mg/dl.

The very high level of triglycerides is greater than the 150 mg/dl. The triglycerides cholesterol associated with pancreatitis and it requires medical treatment. 

Screening Age

The health organizations do not have a consensus on the age to begin the screening for hyperlipidemia.

But the CDC can recommend cholesterol screening once between the ages of 9 and 11, and again between the 17 and 21 age and also every 4 to 5 years in adulthood.

The healthcare provider may also recommend for the more frequent screening if the person has a family history of early heart attacks, heart disease, or if the child is having diabetes or obesity.

The USPSTF can recommend for the screening men who are older than 35 and women older than 45.

The NCE-ATP III can recommend all adults older than 20 for the screening because it may lead to the potential lifestyle modification that can help to reduce the risk of other diseases.

However, the screening is done for those with the known CHD or the risk of equivalent conditions which include:

  • Acute coronary syndrome 
  • Stable or unstable angina 
  • The peripheral arterial disease of atherosclerotic origin
  • History of heart attack 
  • Transient ischemic attacks 
  • Coronary or other arterial revascularization. 

Screening Frequency

The adults 20 years and older should have the cholesterol check every 4 to 6 years. While most of the screening guidelines recommend cholesterol testing every 5 years.

USPSTFcan recommends to increase the frequency for the people with an elevated risk of CHD, which can determine the use of cardiovascular diseases or risk scores. 

How To Prevent Mixed Hyperlipidemia?

flat belly and healthy foods

While there are many risk factors, that cannot be controlled. But making some lifestyle changes can help to prevent or reduce the risk of hyperlipidemia.

Lifestyle changes can also help to reduce cholesterol and triglyceride levels. For reducing the risk of heart disease doctors may suggest a low- calories diet, regular exercise, and weight loss.

According to the American Heart Association, a low-fat diet can help to lessen down the risk of heart disease.

Some evidence also suggests that cutting out the sugar level and reducing the carbohydrates is effective in lowering both weight and triglycerides while increasing HDL.

Here are some tips that can manage your cholesterol: 

1. Quit Smoking 

Smoking lowers HDL cholesterol in the body. People with unhealthy cholesterol levels and also smokes can increase the risk of coronary heart disease.

Because smoking is also a compound of the risk that is present by the other risk factors for heart disease, such as diabetes and high blood pressure.

It also promotes atherosclerosis and increases the LDL, encourages inflammation, and the formation of blood clots.  Quitting smoking can increase the higher HDL levels in the body.

This is one of the reasons why the risk of cardiovascular disease decreases after a person stops smoking.

A person with hyperlipidemia can reduce the risk of cardiovascular problems later in life by strictly following the diet and also treatment plan that they recommend by their doctors.  

2. Lose Weight 

People who are overweight or obese are also at a greater risk of developing heart disease and hyperlipidemia.

Because being overweight can raise the LDL cholesterol level and also lower the HDL cholesterol. Losing weight can help to reduce LDL, triglyceride, and total cholesterol.

It also boosts the HDL cholesterol in the body, which helps to remove the LDL from the blood. 

Losing weight of as little as 10 percent can help to improve the high cholesterol numbers in the body. 

3. Physical Activity 

A sedentary lifestyle can Lower HDL cholesterol. Less HDL means there’s less good cholesterol to remove LDL cholesterol from the arteries.

A lack of physical activity is also another risk factor of heart disease. Doing just 150 minutes of moderate-intensity aerobic exercise a week can help to reduce the LDL cholesterol and raise the HDL cholesterol level in the body.

Doing regular exercise or activities can also encourage weight loss. The American  Heart Association recommends that people do 150 minutes of moderately intense physical activity every week.

There are lots of physical activity options such as bicycling, swimming, brisk walking, or even dancing that can fit the bill. But the important thing is to find a routine that you will stick to. 

4. Mixed Hyperlipidemia Diet

According to the dietary, the best way to lower the cholesterol level is to reduce the saturated fat and trans fat from the diet.

The American heart association recommends limiting saturated fat to 5 to 6 percent of daily calories and also minimizing the amount of trans fat that you eat.

Reducing these fats means limiting the intake of red meat and dairy products that are made with whole milk. Also limiting fried or fast food and cooking with healthy oils such as vegetable oil.

Consuming a heart-healthy diet emphasizes vegetables, fruits, nuts, poultry, and whole grains while curbing the sugary foods and beverages. Eating this way can increase fiber intake, which is beneficial for hyperlipidemia.

A diet which is high in fiber can help to lower cholesterol levels as much as 10 percent.

People should also try to restrict or eliminate fast foods, which are high in carbohydrates foods, and also any processed foods or foods that do not offer good nutritional value.

The DASH eating plan can be promoted by the national heart, lung, and blood institute, as well as diets, also suggested by the U.S. The Department of Agriculture and The American Heart Association, are all heart-healthy approaches.

While such a diet can also adapt that base on the people’s culture and food preferences.

So, become smarter about what you eat, so you will need to pay more attention to food labels. As a starting point: 

Know your fats: Knowing which fats raise LDL cholesterol and which ones don’t is key to lowering the risk of heart disease. 

Cooking for lower cholesterol: A heart-healthy eating plan can also help you manage your blood cholesterol level.  

Mixed Hyperlipidemia Treatments

Hyperlipidemia Treatments

Let’s discuss mixed hyperlipidemia treatment guidelines

Mixed hyperlipidemia is an inherited disorder that has no cure. Self-management of hyperlipidemia[4] through a balanced diet and also regular physical activity, that may help a person to reduce the levels of lipoproteins in their blood.

However, genetics also determine the cholesterol levels, so a healthy lifestyle may not always be enough to reduce cholesterol. Some individual people also require medications.

Typically, doctors also prescribe statins, such as rosuvation, atorvastatin, lovastatin, simvastatin for reducing cholesterol levels. [5]

These medications can help to decrease the amount of cholesterol the liver produces. Statins can also cause side effects which include muscle pain. The muscle pain is usually harmless, but it happens in rare cases.

It may also cause muscle breakdown and damage. Anyone who is finding the pain hard to tolerate then, they should talk to their doctor before stopping to take the drugs.

It is essential to balance the risk of a cardiovascular event against the risk of side effects before stopping the treatment with the stains. People who have a higher cholesterol level then they do not reach their desired target after taking the stains.

For the desired results they need higher doses of statin medications or additional medications. Some other non-statin medications include ezetimibe and the less common, fibrates or niacin.

One new guideline suggests that the PCSK9 inhibitor is also available such as evolocumab. PCSK9 inhibitors are expensive, that’s why the doctors should take this into the account before prescribing them.

However, the guidelines also recommend a  lower price for these medications to allow the specific population’s access to the drug.

This will include people with inherited hyperlipidemia, who may not be able to take these medications they need or those who had a heart attack and also cannot achieve their LDL gels with the other drugs. 

Mixed Hyperlipidemia Medications

take a Medications in Mixed Hyperlipidemia

The people who have mixed hyperlipidemia and their cholesterol levels remain high after changing their lifestyle.

The doctor may prescribe the medication to control the cholesterol level. There are several drugs available that can help you to manage the cholesterol level.

Each medication is works differently to change the cholesterol level in the body, which include:

1. Stains

Stains are usually the first-line treatment. It is also the most commonly prescribed medication for lowering cholesterol.

Because it also blocks the substance that the liver needs to make cholesterol. This will cause your liver to remove cholesterol from the blood.

Stains can also help the body to reabsorb the cholesterol from the built-up deposits on the artery walls, potentially reversing coronary artery disease.

Choices include fluvastatin, lovastatin, simvastatin, pravastatin, pitavastatin, and rosuvastatin. 

2. Bile-acid-binding Resins

The liver uses cholesterol to make bile acid in the liver. It is an important substance that is needed for digestion. Thus medication gets into the liver to make more bile acids.

The medications colestipol, colesevelam, and cholestyramine can lower the cholesterol indirectly by binding the bike acids.

The bile-acid binding resin can promote the liver to use the excess cholesterol to make the more bile acids that can help to reduce the cholesterol level in the blood. 

3. Cholesterol Absorption Inhibitors

The small intestine can absorb the cholesterol from the daily diet and release this cholesterol into the bloodstream.

Ezetimibe drugs can help to reduce blood cholesterol by limiting the absorptions of dietary cholesterol. Zetia has been used in combination with any of the statin drugs. 

4. Combination Of Cholesterol Absorption Inhibitor And Statin

The combination of the drug ezetimibe-simvastatin can help to decrease the both absorption of dietary cholesterol in the small intestine and also the production of the cholesterol in the liver.

It is unknown whether Vytorin is more effective in reducing heart disease risk than taking the simvastatin by itself.

5. Injectable Medications 

 A new class of drugs can help the liver to absorb more LDL cholesterol, which helps to lower the amount of cholesterol circulating in the blood.

The Food and Drug Administration recently approved the alirocumab and evolocumab for the people who have a genetic condition that can cause very high levels of LDL cholesterol.

These drugs may also be used for people who had a heart attack or stroke which needs additional lowering to their LDL cholesterol levels. These injectable drugs are administered at home one or two times a month. 

6. Sterol Absorptions

Inhabitors or the intsestioansiel sterol absorptions such as the ezetimibe. It decreases the absorption of cholesterol in the GI Tract by reducing the NPC1L1, gastrointestinal wall, and a transport protein.

This can help to decrease the LDL cholesterol level. Some people may also have side effects from a particular drug or combination of the drugs.

For instance, some people can’t tolerate statins. In this case, doctors will work to find another drug option for the treatment. Doctors will also monitor the treatment progress with regular lab tests.

Doctors may also want to monitor the effects of the medication on liver function. New information about the treatment is still coming out.

If any have mixed hyperlipidemia, then they should consult with the doctors regularly about the research updates. 

Medications For Triglycerides

Management of mixed hyperlipidemia includes the maintenance of normal body weight and increased physical activities, and also decreases the consumption of refined carbohydrates and simple sugars.

Prescription of drugs may also be used to treat some people having significant risk factors such as cardiovascular disease.

Here are some medications that doctors may prescribe if you have a triglyceride.

1. Fibrates

The fibrates medications such as fenofibrate and gemfibrozil can help to decrease triglycerides by reducing the production of very-low-density lipoprotein cholesterol and also by speeding up the removal of triglycerides from the blood.

But in some people, it may cause major side effects such as, myopathy, GI upset, rashes or it increases the transaminases. 

2. Niacin

Niacin can also decrease the triglycerides by limiting the liver ability that produces the VLDL and LDL cholesterol. But niacin doesn’t usually provide any additional benefits than using the statins alone.

Niacin also links with liver damage and stroke. That’s what most of the doctors now recommend it only for those people who cannot take the statins. 

3. Omega-3 Fatty Acids Supplements 

Some doctors also recommend omega-3 fatty acids supplements for the treatment of mixed hyperlipidemia.

Because Omega-3 fatty acid supplements can help to lower the triglycerides in the body. These supplements are available by prescription or over the counter.

So if you choose to take it over the counter supplements then consult with your doctors first.

Because Omega-3 fatty acids supplements can affect the other medications if you are also taking. One of the common side effects is flushing secondary to skin vasodilation. 

The tolerance or side effects of the medications varies from person to person. But the common side effect is diarrhea, nausea, stomach pain, constipation, and muscle pains. 

What Is Mixed Hyperlipidemia icd 10?

It is the billable code that is used to specify the medical diagnosis or mixed hyperlipidemia. Hld icd 10 code is only valid for the year 2020 for the submission of the HIPAA-covers transactions.

The ICD-10- cm code may also be used to specify the conditions or the terms like alpha/ beta lipoproteins, eruptive xanthoma, a familial disease with the storage of sterols, benign tumor of the dermis, and the familial type 3 hyperlipoproteinemia. 

Does Mixed Hyperlipidemia run in families as a Genetic disorder?

The familial hypercholesterolemia. In this, the LDL cholesterol levels are very high

Familial Hypertriglyceridemia: In hypertriglyceridemia the triglycerides levels are high.

Familial Mixed hyperlipidemia: In this the level of LDL cholesterol, triglycerides, or both cholesterol is high and the level of HDL is low. 

The mixed hyperlipidemia is also related to a hormonal disease such as diabetes, hypothyroidism.

Cushing’s syndrome which includes too much cortisol sometimes is called the stress hormone. Certain medications can also cause mixed hyperlipidemia.

  • Birth controls pills
  • Some diuretics like water pills
  • Beta-blockers to treat cardiovascular diseases
  • Menopausal hormone therapy. 


Mixed hyperlipidemia is one of the major risks of heart disease. It also refers to the excess levels of LDL cholesterol and also increases the triglycerides in the blood.

Some doctors also consider the low density of lipoprotein or LDL as bad cholesterol and the high density of lipoproteins as good cholesterol.  Hyperthyroidism, consuming a high-fat diet, and being overweight also contribute to high cholesterol.

However, some types of hyperlipidemia have genetic causes. Doing regular physical activities and eating a diet that contains all the healthy fats can help to balance the cholesterol level in the blood.

This will also help to prevent health-related problems. The outlook also depends on how early you diagnose the mixed hyperlipidemia and how you respond to the prescribed treatment plans.

It will also depend on how you stick to the plan. If you left it untreated, then the mixed hyperlipidemia will put you on the high risk such as early heart attack or stroke.

But maintaining the healthy lifestyle changes and medication can help to maintain the lipid levels.

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